5-Amino-1MQ vs Macimorelin
Head-to-head comparison of 5-Amino-1MQ (5-Amino-1-methylquinolinium) and Macimorelin (Macimorelin acetate (AEZS-130)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | 5-Amino-1MQ | Macimorelin |
|---|---|---|
| Category | Weight Management | Growth Hormone |
| Full Name | 5-Amino-1-methylquinolinium | Macimorelin acetate (AEZS-130) |
| Molecular Weight | 178.23 g/mol | N/A |
| Half-Life | ~6 hours | about 4-6 hours |
| Amino Acids | Small molecule | N/A |
| Typical Dose | — | 0.5 mg/kg single oral dose |
| Route | — | Oral |
| Purity | >98% | ≥98% |
| Studies Count | 28 | 120 |
| Research Status | Active Research | Clinical |
5-Amino-1MQ Benefits
- ✓Reduces body fat without appetite changes, lowers cholesterol, increases NAD+ levels, improves metabolic efficiency, supports cellular energy production
Macimorelin Benefits
- ✓diagnostic GH stimulation
- ✓single oral dose
- ✓rapid measurable GH response
- ✓high clinical utility
5-Amino-1MQ Dosing
Research doses: 50-150 mg orally daily. Often cycled 8-12 weeks on, 4 weeks off. Best taken in the morning.
Macimorelin Dosing
0.5 mg/kg orally as a single dose|fasted testing conditions|serial GH sampling after administration
5-Amino-1MQ Side Effects
- ⚠Generally well-tolerated in preclinical models. Potential mild GI discomfort and headache. Long-term human safety data is limited.
Macimorelin Side Effects
- ⚠dysgeusia or taste disturbance
- ⚠nausea
- ⚠headache
Research Overview
5-Amino-1MQ
Studies in diet-induced obese mice showed significant reductions in body weight, white adipose tissue mass, and cholesterol levels without changes in food intake. Works by inhibiting NNMT enzyme to increase NAD+ and activate sirtuins.
Macimorelin
Macimorelin has been validated in clinical testing as an oral alternative to injectable GH stimulation tests. Its short-term use makes it a useful translational tool for evaluating pituitary GH reserve.
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