Pidotimod vs Thymalin
Head-to-head comparison of Pidotimod (3-L-Pyroglutamyl-L-Thiazolidine-4-Carboxylic Acid) and Thymalin (Calf Thymus Peptide Fraction (Thymalin)) — benefits, dosing, side effects, research data, and where to buy.
| Property | Pidotimod | Thymalin |
|---|---|---|
| Category | Immune Support | Immune Support |
| Full Name | 3-L-Pyroglutamyl-L-Thiazolidine-4-Carboxylic Acid | Calf Thymus Peptide Fraction (Thymalin) |
| Molecular Weight | 244.27 Da | N/A |
| Half-Life | 3-4 h | N/A |
| Amino Acids | 2 | N/A |
| Typical Dose | 400-800 mg/day | 5-20 mg |
| Route | Oral | Intramuscular |
| Purity | ≥98% | ≥98% |
| Studies Count | 200 | 120 |
| Research Status | Clinical | Clinical |
Pidotimod Benefits
- ✓oral-immune-support
- ✓respiratory-infection-adjunct
- ✓innate-immunity
- ✓adaptive-immunity-support
Thymalin Benefits
- ✓t-cell support
- ✓leukocyte recovery
- ✓immunomodulation
- ✓infection-resilience
Pidotimod Dosing
400 mg PO BID|typically 15-30 days|repeated seasonal cycles in studies
Thymalin Dosing
5-10 mg IM daily|3-10 day cycles|repeat cycles after 1-4 weeks if studied
Pidotimod Side Effects
- ⚠nausea
- ⚠diarrhea
- ⚠rash
Thymalin Side Effects
- ⚠injection-site discomfort
- ⚠transient fever
- ⚠rash/allergy
Research Overview
Pidotimod
Pidotimod has human data in recurrent infections, especially where immune stimulation or reduced infection frequency is the target. Published work commonly reports improvements in phagocyte function, mucosal defense, and fewer respiratory infection episodes.
Thymalin
Thymalin appears in Soviet/Russian clinical literature as a thymus peptide complex used to normalize immune parameters after illness, surgery, or radiation exposure. Reports commonly focus on changes in lymphocyte subsets, phagocytic activity, and infection frequency rather than a single isolated peptide mechanism.
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