Omentin-1 vs PT-141
Head-to-head comparison of Omentin-1 (Omentin-1 (Intelectin-1, ITLN1)) and PT-141 (Bremelanotide (Melanocortin Receptor Agonist)) — benefits, dosing, side effects, research data, and where to buy.
| Property | Omentin-1 | PT-141 |
|---|---|---|
| Category | Diabetes & Metabolic | Performance |
| Full Name | Omentin-1 (Intelectin-1, ITLN1) | Bremelanotide (Melanocortin Receptor Agonist) |
| Molecular Weight | ~35 kDa | 1,025.2 Da |
| Half-Life | hours | ~2.7 hours |
| Amino Acids | 313 | 7 |
| Typical Dose | No approved human dose; research use only | 1.75 mg |
| Route | IV|SC | SC |
| Purity | ≥98% | — |
| Studies Count | 82 | 178 |
| Research Status | Pre-clinical | FDA Approved |
Omentin-1 Benefits
- ✓insulin sensitivity
- ✓glucose uptake
- ✓lipid handling
PT-141 Benefits
- ✓Enhances sexual desire and arousal
- ✓Works through CNS (not vascular)
- ✓FDA-approved for HSDD
- ✓Effective for both men and women
- ✓Does not require sexual stimulation to work
Omentin-1 Dosing
not established|not established
PT-141 Dosing
Standard: 1.75 mg SC, 45 min before activity|Max frequency: Once every 24 hours|Max: 8 doses per month|Men (off-label): 1-2 mg SC as needed
Omentin-1 Side Effects
- ⚠unknown
- ⚠immunogenicity risk
PT-141 Side Effects
- ⚠Common: Nausea (40%), flushing, headache, injection site reactions
- ⚠Moderate: Elevated blood pressure (transient), fatigue
- ⚠Serious: Focal hyperpigmentation with repeated use
- ⚠Contraindications: Uncontrolled hypertension, cardiovascular disease
Research Overview
Omentin-1
Lower omentin-1 levels are often associated with obesity, insulin resistance, and metabolic syndrome. Research continues on its use as a biomarker and as a mechanistic lead for AMPK-linked metabolic interventions.
PT-141
PT-141 has robust clinical evidence including multiple Phase III trials. FDA-approved in 2019. Unique mechanism of action through melanocortin-4 receptors in the brain. Well-characterized safety and efficacy profile.
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