Insulin Lispro vs Leu-enkephalin
Head-to-head comparison of Insulin Lispro (Insulin lispro (B28-Lys, B29-Pro human insulin analog)) and Leu-enkephalin (Tyr-Gly-Gly-Phe-Leu) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Insulin Lispro | Leu-enkephalin |
|---|---|---|
| Category | Diabetes & Metabolic | Pain Management |
| Full Name | Insulin lispro (B28-Lys, B29-Pro human insulin analog) | Tyr-Gly-Gly-Phe-Leu |
| Molecular Weight | 5808.0 Da | 555.63 Da |
| Half-Life | About 1 hour | 1-5 minutes in plasma |
| Amino Acids | 51 | 5 |
| Typical Dose | 0.05-0.2 U/kg per meal | 0.1-5 ug per animal |
| Route | Subcutaneous | Intrathecal / intracerebroventricular |
| Purity | ≥98% | ≥98% |
| Studies Count | 12000 | 1000 |
| Research Status | Approved | Pre-clinical |
Insulin Lispro Benefits
- ✓Rapid postprandial glucose control
- ✓Flexible premeal timing
- ✓Predictable onset of action
- ✓Useful in basal-bolus regimens
Leu-enkephalin Benefits
- ✓delta-opioid activity
- ✓endogenous analgesic model
- ✓receptor-selective pharmacology
- ✓nociception pathway research
Insulin Lispro Dosing
Inject SC 0-15 minutes before meals|Adjust dose to carbohydrate intake and premeal glucose|Often paired with a basal insulin
Leu-enkephalin Dosing
Intrathecal 0.1-5 ug per animal|Intracerebroventricular 0.1-2 ug per animal|In vitro 1-100 nM
Insulin Lispro Side Effects
- ⚠Hypoglycemia
- ⚠Weight gain
- ⚠Injection-site reactions
Leu-enkephalin Side Effects
- ⚠sedation
- ⚠constipation-like opioid effects
- ⚠very short plasma stability
Research Overview
Insulin Lispro
Clinical studies show faster onset and shorter duration than regular insulin, improving post-meal glucose control. It is a standard comparator in diabetes pharmacology and closed-loop insulin-delivery research.
Leu-enkephalin
Leu-enkephalin is a standard tool in opioid receptor and pain-transmission research because it helps distinguish delta- from mu-preferring signaling. Its research value is high, but its clinical utility is limited by rapid enzymatic breakdown and delivery challenges.
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