Insulin Lispro vs GLP-1
Head-to-head comparison of Insulin Lispro (Insulin lispro (B28-Lys, B29-Pro human insulin analog)) and GLP-1 (Glucagon-like peptide-1 (7-36 amide)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Insulin Lispro | GLP-1 |
|---|---|---|
| Category | Diabetes & Metabolic | Diabetes & Metabolic |
| Full Name | Insulin lispro (B28-Lys, B29-Pro human insulin analog) | Glucagon-like peptide-1 (7-36 amide) |
| Molecular Weight | 5808.0 Da | 3297 Da |
| Half-Life | About 1 hour | 1-2 minutes |
| Amino Acids | 51 | 30 |
| Typical Dose | 0.05-0.2 U/kg per meal | Research-only: 0.1-1.0 pmol/kg/min |
| Route | Subcutaneous | Intravenous/Subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 12000 | 1200 |
| Research Status | Approved | Pre-clinical |
Insulin Lispro Benefits
- ✓Rapid postprandial glucose control
- ✓Flexible premeal timing
- ✓Predictable onset of action
- ✓Useful in basal-bolus regimens
GLP-1 Benefits
- ✓beta-cell protection
- ✓improved insulin secretion
- ✓slower gastric emptying
- ✓lower postprandial glucose
Insulin Lispro Dosing
Inject SC 0-15 minutes before meals|Adjust dose to carbohydrate intake and premeal glucose|Often paired with a basal insulin
GLP-1 Dosing
0.1-1.0 pmol/kg/min IV infusion in research|0.5-10 nM in vitro|continuous delivery in animal studies
Insulin Lispro Side Effects
- ⚠Hypoglycemia
- ⚠Weight gain
- ⚠Injection-site reactions
GLP-1 Side Effects
- ⚠nausea at pharmacologic exposure
- ⚠tachyphylaxis with continuous exposure
- ⚠headache
Research Overview
Insulin Lispro
Clinical studies show faster onset and shorter duration than regular insulin, improving post-meal glucose control. It is a standard comparator in diabetes pharmacology and closed-loop insulin-delivery research.
GLP-1
Native GLP-1 has a very short half-life because of rapid DPP-4 cleavage, so it is mainly used as a mechanistic research peptide. Across animal and cellular studies it reduces beta-cell apoptosis, improves insulin gene expression, and enhances islet resilience.
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