Histatin-5 vs NPY
Head-to-head comparison of Histatin-5 (Human histatin 5) and NPY (Neuropeptide Y) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Histatin-5 | NPY |
|---|---|---|
| Category | Dental & Oral | Cognitive Enhancement |
| Full Name | Human histatin 5 | Neuropeptide Y |
| Molecular Weight | 3035 Da | 4272 Da |
| Half-Life | minutes in saliva | minutes |
| Amino Acids | 24 | 36 aa |
| Typical Dose | 1-100 µM in research formulations | 1-10 µg preclinical range |
| Route | Topical/Oral rinse | Intranasal |
| Purity | ≥98% | ≥98% |
| Studies Count | 120 | 900 |
| Research Status | Pre-clinical | Pre-clinical |
Histatin-5 Benefits
- ✓anti-Candida activity
- ✓biofilm suppression
- ✓mucosal wound support
- ✓oral innate immunity
NPY Benefits
- ✓stress resilience
- ✓hippocampal protection
- ✓memory modulation
- ✓anti-excitotoxic signaling
Histatin-5 Dosing
topical rinse or gel|short contact exposure|repeat applications in research protocols
NPY Dosing
0.1-1 nmol ICV in rodents|1-10 µg intranasal in experimental work|acute or repeated stress-model protocols
Histatin-5 Side Effects
- ⚠local irritation
- ⚠proteolytic instability
- ⚠dose-dependent cytotoxicity in vitro
NPY Side Effects
- ⚠sedation
- ⚠appetite increase
- ⚠blood pressure changes
Research Overview
Histatin-5
Histatin-5 is a major salivary defense peptide that can kill Candida species and influence oral microbial communities. It is also investigated for wound-healing and xerostomia-associated oral infection models.
NPY
NPY has been shown in animal studies to protect neurons from excitotoxic injury and to dampen stress-linked cognitive impairment. It is often discussed as a counterbalance to overactive glutamatergic and stress pathways in the brain.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.