GHRP-6 vs Ipamorelin
Head-to-head comparison of GHRP-6 (Growth Hormone Releasing Peptide-6) and Ipamorelin (Growth Hormone Secretagogue) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | GHRP-6 | Ipamorelin |
|---|---|---|
| Category | Performance | Performance |
| Full Name | Growth Hormone Releasing Peptide-6 | Growth Hormone Secretagogue |
| Molecular Weight | 873.01 Da | 711.85 Da |
| Half-Life | ~15-60 minutes | ~2 hours |
| Amino Acids | 6 | 5 |
| Typical Dose | 100-300 mcg | 200-300 mcg |
| Route | SC / IV | SC |
| Purity | — | — |
| Studies Count | 186 | 156 |
| Research Status | Clinical Trials | Clinical Trials |
GHRP-6 Benefits
- ✓Potent GH release stimulation
- ✓Muscle growth and strength
- ✓Appetite stimulation (ghrelin pathway)
- ✓Improved body composition
- ✓Enhanced recovery from training
Ipamorelin Benefits
- ✓Stimulates natural GH release
- ✓Minimal cortisol/prolactin increase
- ✓Improved body composition
- ✓Enhanced recovery and sleep quality
- ✓Anti-aging effects
GHRP-6 Dosing
Standard: 100-300 mcg SC 2-3 times daily|Pre-workout: 100 mcg 30 min before training|Pre-bed: 100-200 mcg for overnight GH pulse
Ipamorelin Dosing
Standard: 200-300 mcg SC 2-3 times daily|Pre-bed: 200 mcg SC 30 min before sleep|Combined: 100-200 mcg with CJC-1295 2-3x daily
GHRP-6 Side Effects
- ⚠Common: Increased appetite (significant), water retention, tingling
- ⚠Moderate: Cortisol elevation (dose-dependent), lethargy
- ⚠Rare: Elevated prolactin at high doses
Ipamorelin Side Effects
- ⚠Common (Mild): Temporary tingling, water retention, increased appetite
- ⚠Rare: Headache, lightheadedness
- ⚠Very Well Tolerated overall
Research Overview
GHRP-6
GHRP-6 has solid pre-clinical and clinical evidence for GH stimulation. Well-characterized pharmacology. More appetite stimulation than Ipamorelin due to ghrelin receptor activation.
Ipamorelin
Ipamorelin has moderate clinical evidence. Phase II trials demonstrate selective GH release. Generally regarded as one of the safest GH secretagogues with minimal side effect profile.
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