Elamipretide vs NPY
Head-to-head comparison of Elamipretide (Elamipretide (MTP-131, SS-31)) and NPY (Neuropeptide Y) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Elamipretide | NPY |
|---|---|---|
| Category | Muscle & Performance | Cognitive Enhancement |
| Full Name | Elamipretide (MTP-131, SS-31) | Neuropeptide Y |
| Molecular Weight | 639.8 Da | 4272 Da |
| Half-Life | 1-4 hours | minutes |
| Amino Acids | 4 | 36 aa |
| Typical Dose | 0.01-0.25 mg/kg/day | 1-10 µg preclinical range |
| Route | Subcutaneous/Intravenous | Intranasal |
| Purity | ≥98% | ≥98% |
| Studies Count | 120 | 900 |
| Research Status | Clinical | Pre-clinical |
Elamipretide Benefits
- ✓mitochondrial protection
- ✓reduced oxidative stress
- ✓improved fatigue resistance
- ✓may support exercise tolerance
NPY Benefits
- ✓stress resilience
- ✓hippocampal protection
- ✓memory modulation
- ✓anti-excitotoxic signaling
Elamipretide Dosing
0.01-0.25 mg/kg/day SC (clinical research)|daily dosing in trials|alternative IV protocols in some studies
NPY Dosing
0.1-1 nmol ICV in rodents|1-10 µg intranasal in experimental work|acute or repeated stress-model protocols
Elamipretide Side Effects
- ⚠nausea
- ⚠injection-site reactions
- ⚠diarrhea
- ⚠headache
NPY Side Effects
- ⚠sedation
- ⚠appetite increase
- ⚠blood pressure changes
Research Overview
Elamipretide
Clinical and translational studies show elamipretide can improve mitochondrial function and some functional endpoints in mitochondrial disorders. Skeletal muscle research suggests benefits are driven by energy metabolism rather than direct muscle-building effects.
NPY
NPY has been shown in animal studies to protect neurons from excitotoxic injury and to dampen stress-linked cognitive impairment. It is often discussed as a counterbalance to overactive glutamatergic and stress pathways in the brain.
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