Arenicin-1 vs GPE

Head-to-head comparison of Arenicin-1 (Arenicin-1) and GPE (Glycyl-L-prolyl-L-glutamic acid) — benefits, dosing, side effects, research data, and where to buy.

Research Score

PropertyArenicin-1GPE
CategoryMarine-DerivedCognitive Enhancement
Full NameArenicin-1Glycyl-L-prolyl-L-glutamic acid
Molecular Weight2079 Da301.30 Da
Half-Lifen/aminutes
Amino Acids213
Typical Dosen/a0.1-10 mg/kg preclinical
RoutepreclinicalIntranasal/Intracerebroventricular
Purity≥98%≥98%
Studies Count7625
Research StatusPre-clinicalPre-clinical

Arenicin-1 Benefits

  • antimicrobial
  • anti-biofilm
  • membrane-active

GPE Benefits

  • memory consolidation
  • neuroprotection
  • synaptic plasticity
  • learning support

Arenicin-1 Dosing

bacterial infection|biofilm disruption

GPE Dosing

intranasal or ICV research doses|0.1-10 mg/kg preclinical range|repeat daily or intermittent protocols

Arenicin-1 Side Effects

  • Arenicola marina

GPE Side Effects

  • limited human safety data
  • short half-life
  • local irritation with nasal delivery

Research Overview

Arenicin-1

Marine annelid peptide with strong preclinical antibacterial activity and a stable structural motif that is useful for peptide engineering.

GPE

Preclinical studies suggest GPE can reduce neuronal damage and support plasticity-related pathways in the brain. Research interest centers on hippocampal function, which links it to learning and memory paradigms.

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Common Stacking Partners

Arenicin-1 stacks with:

Arenicola marinabeta-hairpinantibiotic

GPE stacks with:

davunetidenoopeptarginine-vasopressin
marine-derivedbioactiveantimicrobial peptidebiofilmtripeptideneuroprotectionmemory